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Archive for the ‘LED Information’ Category

LED for ACNE, Wrinkles and Viruses

Light that can cure you

Exciting new research provides doctors with an alternative treatment to drugs or surgery for ailments ranging from acne to Alzheimer’s.

By Reed Karaim

http://www.usaweekend.com/07_issues/070204/070204health.html

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Anti-Aging

LED (light emitting diodes) is quickly gaining popularity in the area of Anti-Aging for Wrinkles, Balding, Acne, and Scarring in both the medical and aesthetic fields. 

With over 12 years of clinical research, 60 plus clinical papers and 6 FDA clearances the The LED Therapy Center has done its research on which LED equipment provides the optimal wavelength and intensity to target and reverse the signs of aging, balding, and acne.  

Understanding how “light” interacts with the body (the body needs light to thrive and heal) The LED Therapy Center uses LED equipment/lights based on many years of medical research. Dr. Colin Whitehurst was commissioned by Cancer Research U.K. to develop a device that delivered effective “light therapy” for the treatment of skin cancers over 25 years ago.  His research revealed how to optimize the interaction between light energy (photons) and the cell.  Now with over 60 independent peer reviewed publications from leading physicians effective protocols have been established for treatments.

The best part about LED lights from the LED Therapy Center is that they work with the body’s own biochemistry to reverse the signs and effects of aging.  Cells with receptors for absorbing light in the form of energy (photons) react by consuming the light waves which stimulate normal cellular processes.  Exposure to LED accelerates and improves the natural repair and immune response of cells to regenerate and proliferate.   Proper wavelength, intensity and exposure combined, prove to optimize LED results

And, the results keep accumulating over time.  LED treatments affect the cell deep in the dermis (skin) where skin cells are born. By igniting or turning on the energy (ATP) of the cell, fibroblast begin to awaken dormant collagen and elastin strands.  Clinical studies have reported a 74% improvement in periorbitral wrinkles and 84% in skin clarity and smoothness.  LED lights from the LED Therapy Center provide optimal fuel for dying head hair follicles, collagen and elastin production and so much more. 

Finally there is hope for Acne suffers who have tried it all.  LED lights prove to exceed all previous treatments and solutions.  By killing the bacteria (core cause) that feed on the sebaceous oil (causing inflammation) and purging the pores of impurities, the skin heals.  With no pain, no downtime, no red irritated or scabby skin, LED’s shine in the area of acne solutions and treatments.  Plus the anti-aging effects from LED give acne prone skin the best way to fade discoloration, shrink pores and scars!

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Conditions helped by LED

Conditions and Injuries Helped by LEDs

Conditions known to be helped by LED light therapy

Conditions LED light therapy may or may not help

  • wrinkles, aging, acne, spots (see skin section)
  • bone healing (it might help)
  • existing bruises and inflammation
  • back pains (hit or miss)
  • rosacea, psoriasis, eczema, dermatitis, poison ivy

Conditions LED light therapy does not help

  • headache
  • muscle ache from working out
  • infection
  • scars
  • bunion reduction
  • reverse osteoarthritis bone deformation
  • any injury too deep or beneath bone like the brain

FDA allows advertising red and infrared for minor pains and mild arthritis.  Red has been used to help halt dry macular degeneration which may have FDA approval.  The following have FDA approval for specific devices: infrared 880 nm for diabetic peripheral neuropathy, 660 nm red for mouth ulcers in children on a type of chemo, “Titan” intense infrared device for wrinkles in a clinical setting, very intense (harmful) infrared devices for spots, and blue or blue/red for acne.  There have been excellent results reported for tendonitis, shoulders, knees, small joints, and fibromyalgia.  For most soft-tissue injuries beneath the skin, the pain goes from an 8 to a 2 (on a scale of 10) after an hour or two of treatment with good home-use LED devices.  For exposed injuries like burns and retina injuries, only 1 to 10 minutes of LED light is used, depending on the device.   Applying LED light for too long cancels the benefits, so the time of application is hard to determine and important: too little light and there is little benefit, and too much light and there is no benefit.  The pain relief can be amazing in burns, cuts, and other wounds even if wound healing is not faster.  The increase in the speed of healing can be directly measured in the injured retinas of rabbit.  It does not help bruises.  Stubbed toes can go from being purple-black to pink in one treatment.  Serious injuries seem to benefit from 3 to 6 treatments/day (as the pain returns) instead of one treatment/day.  Strangely, tendons sore from working-out seem to not receive any pain relief, but chronic tendinitis seems to benefit greatly.  It is beneficial only about 30% of the time in back pain.  Companies have made various strange claims: yellow for wrinkles, green for cancer, and blue for wrinkles.  Recent serious injuries benefit from several treatments per day.

Why does it work?

The wavelengths from 600 to 900 nm pass through blood and water in tissue more easily than other wavelengths.  About 35% of the energy in this range is absorbed by a specific “proton pump” (cytochrome c oxidase, CCO, “complex IV”) in mitochondria.  The light at 4 specific wavelengths “kick-start” the CCO pump into producing more cellular energy, ATP.  The CCO pump is very similar in all animals because it evolved from light-assisted bacteria that were part of the first mitochondria.  The absorption spectrum of blood suddenly drops off to allow these wavelengths to pass through which indicates the evolution of hemoglobin may have been influenced by cells benefiting from these wavelengths.  The immediate increase in respiration that sun causes by this mechanism may help animals increase their activity during the day, in addition to the heat provided by the sun that promotes the release of oxygen (myoglobin also absorbs these wavelengths).  These wavelengths of the Sun can provide the optimum 4 J/cm^2 at a depth of 1 inch (using 1% transmission) after 4 hours of exposure in bright Sun, reaching all skin and a large percentage of muscle tissue in historically-thin humans with minimal clothing.

Evolution Theory Support: There are 5 indications that the benefit of red and near-infrared light is not an accident, but a highly “intelligent” and natural result of evolution. The indications are: 1) The proton pump is the last in a series of 3 pumps which places it in possibly the best location to pull the food conversion process along by “pushing” the final electrons through the chain. This creates electrostatic pull on the electrons further back in the chain. 2) The pump absorbs primarily the red and near-infrared light and the remaining sunlight wavelengths are blocked by water and blood. 3) The pump is the primary absorber of these wavelengths in the body, very roughly about 35%. 4) Oxygenated hemoglobin has a very sharp decline in it’s ability to absorb red and near-infrared which indicates hemoglobin evolved specifically to allow these wavelengths to pass through. The CCO pump has a longer evolutionary history than hemoglobin because it was inherited from bacteria that formed the symbiotic relationship in mitochondria. Decendents of these bacteria still exist as purple bacteria which are used in most research on the CCO pump. 5) Night-time levels of melatonin, but not day-time levels, have been shown by Tiina Karu to completely inhibit the positive effects of infrared light. This indicates that melatonin and its wide swings over 24 hours could have evolved to not inhibit the benefits of sunlight.

Details on cytochrome c oxidase: As the CCO absorbs light, its two copper atoms are either oxidized or reduced to transport electrons that are required to help pump H+ to increase the gradient that allows for more ATP.  This increases respiration (krebs cycle molecules provide the energy). Calcium Ca2+, alkalinity (0.2 units), and oxidation are increased which causes important secondary responses such as transcription factors that increase DNA and RNA activity.  The creation of more ATP increases respiration that increases the production of O-2 oxidation which can be harmful if too much light is applied.  Daily moderate use of light therapy induces up-regulation of antioxidants like MnSOD to counteract the harmful oxidation of O2- in a manner much like moderate exercise.  Resveratrol has a similar action via SIRT1/NAD+ –>FOX3a–>MnSOD.  Like resveratrol and nicotinamide, light therapy increases NAD+ which is known to increase endurance as well as increase MnSOD.  Over the short-term, heavy exercise depletes NAD+ but light exercise increases it (ref).  Light therapy increases GSH (glutathione) which decreases H2O2 that is produced from the extra MnSOD that is converting O-2 to H2O2.  Too much wide-spectrum infrared light, such as that received from 3 hours of bright sunlight, causes too much H2O2 which will increase MMP-1 (at least in the dermis of the skin) which some researchers think could cause photo-aging, but not cancer.

The graph below shows that wavelengths over 900 nm start to get blocked more and more by water.

The graph below shows not much light is able to pass through oxygenated blood (HbO2) when the wavelength is less than 600 nm.

Below is the same data, but INVERTED and expanded in our area of interest.


To use the absorption coefficient to find percent of light transmission through blood, use T = 2.718^(-d*A) where d is depth in cm and A is absorption coefficient.  This is simple absorption equation where light scattering coefficient is not taken into account (negligible for blood).  If there is scattering, replace A with SQRT(3A(A+0.8S)) where S is scattering coeff and 0.8 is anisotropy assumption.

Below is another interesting graph that shows that each mm of melanin in skin is very effective at blocking light, but that layer is very thin (less than 0.005 cm) compared to the small fiber collagen and hemoglobin in the dermis layer (0.1 cm).

930 nm and above
It appears any wavelength longer than 930 nm will start to have too much of its energy blocked by the water in tissue.  See the non-ablative part of the
skin section for how 1000-1500 nm can be used to burn the color out of spot and have other beneficial effects.

Laser Light verses LEDs

There has been a lot of interest and money in low laser light therapy (LLLT) for healing, but there is no reason to believe that the coherent light from a laser is any better than LEDs, sunlight, or halogen lights.  Laser light does not penetrate more deeply and cells do not know the difference: all photons are the same and the benefits are based on the action of each individual photon, not on bulk properties such as all the photons having the same polarity and coherency.  The word “laser” has a superior marketing appeal for companies because it sounds interesting and mysterious.  It also costs a lot which means patients can’t do it on their own.  These are the reasons there has been much more research in LLLT for healing than LEDs and halogens: companies and researchers have expected more profit.  Light therapy is ancient and took on various new forms in the 1900′s before lasers were invented.  At least since 1989 definitive statements were being made in journal articles that lasers are not needed.  To quote the most recognized researcher in LLLT, Professor Tiina Karu: “An analysis of published clinical results from the point of view of various types of radiation sources does not lead to the conclusion that lasers have a higher therapeutic potential than LEDs. …The coherent properties of light are not manifested when the beam interacts with a biotissue on the molecular level….The conclusion was that under physiological conditions the absorption of low-intensity light by biological systems is of purely noncoherent (i.e., photobiological) nature….specially designed experiments at the cellular level have provided evidence that coherent and noncoherent light with the same wavelength, intensity, and irradiation time provide the same biological effect.  Successful use of LEDs in many areas of clinical practice also confirms this conclusion.” (Biomedical Photonics Handbook, 2003).  Thankfully, Dr. Karu is a Russian Professor so we can expect her research to be more honest and scientific compared to U.S. medical research based on corporate profit.  From a journal article: “…according to all available data, does not depend on the coherence of radiation.” Reference: “Photobiological Principles of Therapeutic Applications of Laser Radiation” published by Yu. A. Vladimirov, et al in Biochemistry (Moscow) Volume 69, Number 1 / January, 2004.

Blue, Yellow, and Green

See the skin section for information about how blue can help acne (it’s really violet, near UV-A) .  Blue is about 430 to 485 nm.  Green is 510 to 565 nm.  Yellow is 570 to 590. None of these penetrate the deeper than the skin.  See the skin section for how blue can help.  There are some companies that claim yellow helps remove wrinkles.  I haven’t found any research that’s not funded and conducted by the people who profit from it.

Design info: Comparing LEDs

Designers trying to select LEDs or arrays will have trouble comparing LED brightness from different manufacturers.  The plastic encasings can focus the light and make mcd ratings much higher, but the amount of light coming out is the same.  A 100 mcd LED at +/- 10 degrees (20 degrees angle of output) has the same total amount of light output as a 2,000 mcd LED at +/- 5 degrees (10 degrees).  The equation is: Milliwatt output of an LED = mcd / (683 x P) x 2 x pi x (1-cos(1/2 Angle of output)).  Companies are not exactly consistent in how they measure mcd (millicandela) and the angle output.  Be careful in determining if they are stating 1/2 angle or full angle.  P is the “photopic response factor” ( graph ) that depends on the wavelength.  mcd and P are only meaningful for visible wavelengths (not infrared). P=1 for 555 nm and P=0.061 for 660 nm.  For infrared, the measurement has to be mW/SR where SR=steradians.  SR units are the percentage of a sphere’s surface area, but divide SR by 4π (12.566) to get the percentage.  SR is to a sphere as radians are to a circle.  Replace mcd/(683 x P) with mW/SR for infrared LEDs.  In practice all this is not very useful.  You just have to buy the LEDs and compare them.  All 850 nm LED lamps I’ve tested had the exact same efficiency.  As a rough estimate, the light output energy of an LED is 30% of the input energy.  Strong LEDs use 50 to 100 mA continuously. But 20 mA red LEDs can put out enough light and are very common.  A good and strong 850 nm LED will use 50 mA continuously, but the device will get too hot if you pack the LEDs closely (22 LEDs per square inch for 5 mm packages) and run them anywhere near their max.  0.8 watts per square inch is the maximum energy you can apply to any device that touches skin unless a fan or heat sink is used in order to the skin temperature below 105 F (FDA guideline).  Kind of like a high fever on the skin, except the blood is able to take away the heat.  So at a typical spacing of 12 LEDs per in^2 (2 LED per cm^2) you can apply 66 mW per LED.  That’s 45 mA at 1.55 V for the common 850 nm lamp and 35 mA at 1.9 V for a good 660 nm.  LED spectrums can be generated with this spreadsheet.

Despite all the above, in directly measuring LED strength as described below, I measure only half the intensity reported by the datasheets. Datasheets report very roughly 1/3 of the energy input coming out as light output. I measure only half as much, 1/6th.

You may think the following is crazy, so let me first say the results come out EXACTLY equal to the results expected for my quality assurance check, the Sun. So here it is: it’s possible for anyone to directly measure the light intensity of something using a styrofoam cup, cocoa powder, and a home digital thermometer (accurate to 0.1 or 0.2 degrees C), based on the heat capacity of water. The equation is: mW/cm^2 = 2 cm x C x 4.18 / seconds where 2 cm is the depth of water with dark cocoa powder to make it black water, C is increase in the water’s temp, 4.18 is converting from calories to Joules, and seconds is the time the light was applied (200 seconds works best for high power device, up to 600 seconds for typical low power). The styrofoam cup needs to be cut off at 3 cm and LEDs can’t be too close because air currents cause direct heating from the LEDs. For LED devices too small to cover the surface of the water, apply the light for longer amount of time and multiply the results by the water surface area divided by the surface area of the LED array. Do not take temp measurements in the sun or while the LED device is being applied because the metal absorbs the light and heats up. Water temp must be exactly at room temperature, or more precisely, ending water temp should be above room temp by the same amount that beginning temp was below room temp. Using this direct measurement method, I typically get half of what LED manufacturer’s spec sheets say and I know for self-consistency reasons that spec sheets are wrong. To calculate sun intensity at any time at any location on a sunny day, use this spreadsheet. I originally planned to use the Sun to calibrate this device and method, but it comes out so close to the predicted value for the Sun, no calibration or correction is needed.

Safety Concerns

Heat generation is the primary concern.  Skin temperature should never be more than 41 C (105.8F) to meet FDA regs.  There is no way to know how hot an array will get until it is wrapped as snuggly as possible.  No matter how “cool” a heat-producing device operates, if it’s wrapped good enough and long enough, it can get hot.  It’s not just how much energy goes in, but also how much goes out.  I’ve found around 0.8 Watts per square inch to be the maximum energy that can be put into a device that touches the skin without a fan or special heat sinking.  Eye Safety: Strong blue LED’s are dangerous to your eyes!  White LEDs have been studied for safety, but they have the harmful blue wavelengths in them.  Strong green LEDs have 1/15th the risk of blue.  Strong and focused Red and yellow LEDs appear safe, but I would not stare directly at them for more than a minute.  A 10,000 mcd 660 nm red could be dangerous.

The following section has contradictions and will be improved at a later date

LED

LED Treatments – Through Deep Penetrating Light

Laboratory studies have shown that skin cells grow 150-200 percent faster when exposed to certain LED light wavelengths. Independent research for over 40 years has shown LED red and infrared light delivers powerful therapeutic benefits to living tissue. Both visible red and infrared light has been shown to affect at least 24 different positive changes at a deep level. Visible red light, at wavelengths from 630-660 nanometers, penetrates tissue to a depth of 8-10 mm. LED light is very beneficial in treating problems close to the skins surface such as wounds, cuts, and scars. Skin layers, because of their high blood and water content, absorb red light very readily and deliver enough energy to stimulate a response from the body to heal itself.

LED Photons must be absorbed to produce a biological response. All biological systems have a unique absorption spectrum, this uniqueness determines which wavelengths of light will be absorbed to produce a given therapeutic effect. The visible red and infrared portions of the spectrum have been shown to be highly absorbent and produce unique restorative effects in living tissues. It is thought that light photons are absorbed by the skin and underlying tissue and triggers biological changes within the body in a process know as photobiomodulation. Although the exact mechanism of action is still undergoing study, what is know is that monochromatic light increases oxygen and blood flow, facilitating wound healing.

LED therapy is a non-invasive procedure that activates skin cells with pulses of low-level, non-thermal light energy. LED therapy converts light energy within the skin cells, like photosynthesis, which takes sunlight and converts it into food energy in plants.

LED therapy is one of the few non-invasive tools available that can reverse the appearance of aging skin, such as wrinkles and mottled skin tone.

The LED skin light provides a proprietary lightwave design that penetrates deep into the skin to erase the appearance of aging – fine lines, wrinkles, enlarged pores, and crow’s feet.

Pricing

Photorejuvenation –   $75.00 per session
FAQ

How often and how long should I use the DPL Device?
The DPL™ Device is designed to run for nine (9) minutes per treatment. We recommend taking a maximum of two (2) DPL™ treatments daily for the first month and then two treatments per week after that. If you miss a treatment, don’t worry, just extend the daily treatments for the lost days. You may continue to use the light for the two 9 minute treatments per day after the one month period with no ill effects.
How long until I see results?
Everyone’s skin varies, but most people feel and see a difference in about four treatments. Because of differences in damaged skin, some people will see the benefits almost immediately and others will need more treatments. Because treatments are progressive, we recommend treatments for at least ten (10) weeks, for maximum results.
Do LED Treatments work on everyone?
LED treatments are proven to work on all skin types. There is over a 90% success rate for people using our system.
Can this hurt my eyes?
No studies have been found showing any harmful effects to the eyes when using our product correctly. However, we recommend not staring directly into our LEDs and we have provided a supply of eye shields for your comfort.
Why can’t I see light from some of the LED’s?
These LEDs (880 nm) are on and working properly. You cannot see them because they are in the infrared spectrum, which is not visible to the human eye. Some digital cameras and camcorders will display the infrared lights.
Can I combine LED treatments with other skin care?
Yes. LED treatments can be used alone or with other skin care treatments. Many physicians have found LED treatments to complement other skin care treatments.
Will LED treatments hurt?
No. Unlike lasers or other ablative (skin harming) treatments, LED treatments are non-thermal, non-ablative, and non-invasive. Clients report no discomfort or pain associated with LED treatments.

Is LED therapy and IPL (intense pulse light) therapy the same?
LED Therapy and IPL (Intense Pulsed Light) are different. There are several Commercial IPL systems on the market and they range from 500-1200 nm, but the big difference is in the energy output measured in joules/cm2. IPL typically has a power range of 3-90 Joules. It is closer to laser and because of that more dangerous than LEDs. IPL typically need trained users/aesthetician to administer.

Can I use the LED skin light for balding, acne, rosacea?

LED infrared / red light devices have been used for balding, * rosacea, pain, arthritis and acne. From the search we performed across the internet we have found that DPL LED’s use the same technology as other devices that are making these claims. Since this is a new product for us we are not willing to make any claims that this unit will produce the same results as other available units. This unit is being marketed as a cosmetic device. Most skin devices that are available have been commercial models and very expense. This is the first home model that we feel is reasonable, will cover you entire face with one treatment and we are hearing from our clients that it is producing great results.

* The president of LTP did see her rosacea greatly reduced, crows feet dramatically reduced, pain disappear from her hands and feet after using the light unit for 3 weeks.

What is the difference between Laser or LED?

LED’s produce (non-coherent, monochromatic light; spontaneous emission) – Laser’s produce (coherent, monochromatic light, stimulated emission)

Tiina Karu (1998: The Science of Low-Power Laser Therapy) states that “…the coherence of light is of no importance in low-power laser clinical effects” and “the primary difference between lasers and LED’s is that the laser’s coherent beam produces “speckles” of relatively high power density which can cause local heating of inhomogeneous tissues”.

Currently researchers & scientist agree that LED’s are effective in generating a response within living tissue and hence has a therapeutic effect if used properly.

Most published research on photorejuvenation has been conducted using Lasers and not LED’s. Only within the the last decade have LED’s been produced with a strong enough output power to be beneficial for photo rejuvenation

NASA has produced the best research documentation to date supporting the effectiveness of LED’s to stimulate plants and human tissue. Until more research is completed on the success of LED’s for photorejuvenation the effectiveness is still not supported by extensive research.

To summarize, both LED’s and Laser’s work, but more research is needed to determine their best suited role LED’s will play in photo-rejuvination.

What is the output of the LED skin light?

4 joules cm square

Isn’t it true that we are born with only so much collagen?

Collagen is a protein and as a protein collagen is synthesized (or formed) continuously in your body unless you have certain collagen deficiencies (scurvy or the lack of vitamin C is known to inhibit the production of collagen properly and the skin become fragile, wounds do not heal, skin discolors, among other results). Collagen chains are synthesized as longer precursors called “procollagens” and then transported or secreted into the extra cellular space after it is processed and assembled and these collagen molecules then polymerize to from Type I collagen.

There are 12-27 different collagen types (scientists disagree on the division). Type I collagen is the most abundant in the human body; it is present in scar tissue and is the end product when tissue heals itself by repair. This is the type of collage that our LED lights eventually forms. Type III collagen is the collagen of granulation tissue and is produced quickly by young fibroblasts before the tougher type of I collagen is synthesized. Our LEDs stimulate these fibroblasts which produce Type III collagen which eventually forms Type I collagen.

As we age genetics, (Intrinsic – internal aging) and Environmental (Extrinsic – external aging) slows the skin’s ability to repair itself from free-radical damage. Lasers work on reducing wrinkles by actually damaging the tissue causing Type I collage to be produced in the healing process. Our LED lights are non-invasive and do not harm the skin, but rather stimulate fibroblasts which produce collagen which repairs our skin damage.

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Light Emitting Diodes

Light Emitting Diodes Aid in Wound Healing
Powerful light-emitting diodes (LEDs) have been shown to help heal wounds in laboratory animals and are now being tested on humans at the Medical College of Wisconsin. The LEDs were developed by the National Aeronautics and Space Administration (NASA) to spur plant life in space.

Harry T. Whelan, MD, Professor of Neurology, Pediatrics, and Hyperbaric Medicine at the Medical College of Wisconsin, found that diabetic skin ulcers and other wounds in mice healed much faster when exposed to the special LEDs in the lab. Laboratory research has shown that the LEDs also grow human muscle and skin cells up to five times faster than normal. The study is conducted at the College’s MACC (Midwest Athletes Against Childhood Cancer) Fund Research Center.

“For most wounds, we do not need to interfere with nature’s healing,” Dr. Whelan said. “But this technology may be the answer for problem wounds that are slow to heal.”

The Food and Drug Administration has approved a multi-year investigation of the LEDs as an experimental treatment by a team led by Dr. Whelan. The study, funded by NASA, will specifically examine the technology’s effects on diabetic skin ulcers, serious burns and flesh wounds caused by radiation and chemotherapy treatments. The studies on patients are being done at Children’s Hospital of Wisconsin and Froedtert Hospital.

LEDs are being studied in comparison to and in conjunction with hyperbaric oxygen therapy, a standard treatment in which the patient is placed in a pressurized oxygen chamber to stimulate new cell growth.

In the first 18-month phase of the project, 100 individuals will be studied at Froedtert and Children’s Hospitals. The participants have wounds such as a burn, crush injury, radiation burn, skin graft, diabetic ulcer, or any other wound with poor blood or oxygen supply, that is determined by their physician to be healing slowly or not at all.

In a separate protocol, Dr. Whelan is studying and using the LEDs to promote healing of acute mouth ulcers resulting from chemotherapy and radiation used to treat cancer in children. The treatment is quick and painless.

“Some children who probably would have to be fed intravenously because of the severe sores in their mouths have been able to eat solid food,” said David Margolis, MD, Assistant Professor of Pediatrics and an oncologist at Children’s Hospital, whose pediatric cancer patients are participating in the study. “Preventing this oral mucositis improves the patient’s ability to eat and drink and also reduces the risk of infections in patients with compromised immune systems.”

“So far, what we see in patients and what we see in laboratory cell cultures, all point to one conclusion,” said Dr. Whelan. “The near-infrared light emitted by these LEDs seems to be perfect for increasing energy inside cells. This means whether you’re on Earth in a hospital, working on a submarine under the sea, or on your way to Mars inside a spaceship, the LEDs boost energy to the cells and accelerate healing.”

In another continuing study, Dr. Whelan has also used LED therapy to treat more than 20 individuals with brain cancer tumors without the side effects of traditional or laser surgery. This study, done in collaboration with Glenn A. Meyer, MD, Professor of Neurosurgery, uses LEDs to activate light-sensitive, cancer-killing drugs that can kill tumor cells beyond the surgeon’s reach without harming healthy cells.

LED technology was developed to enhance the growth of plant tissue in space by NASA’s Marshall Space Flight Center and Quantum Devices Inc. of Barneveld, Wisconsin. LEDs have a similar physiological effect on human cells as they do on plant cells. In space, the lack of gravity keeps cells from growing naturally, resulting in slow-growing plant life and loss of bone mass, atrophied muscles, and wounds that do not heal properly in astronauts. LEDs stimulate cytochromes in the body that increase the energy metabolism of cells. Cytochromes are part of the “electron transport chain” that converts sugar into instant energy required by the body to perform all of its actions, such as raising a finger or healing a wound.

Laser light has been shown to have similar effects on growing cells, but lasers are heavy, inefficient, more costly and do not offer the ideal wavelength of light for cell growth. The specially designed near-infrared LED has a longer wavelength than laser light that penetrates deeper — to a depth of 23 centimeters, or more that nine inches — without damaging the skin. Though three times brighter that the sun, the LED is very safe and easy to use, as well as portable. For wound healing, the LED is housed in a 3.5″ by 4.5″ flat array from which it emits a red light that is cool to the touch. An array of LEDs includes three wavelengths to affect various cell types.

An LED array is currently on board a US Navy nuclear submarine for treatment of potential training injuries. Dr. Whelan is a commander in the Navy and a diving medical officer for the Naval Special Warfare Command, which includes the SEAL (Sea, Air and Land) teams. Dr. Whelan has been inducted into the NASA Space Technology Hall of Fame for his research into the use of LEDs for wound healing and the treatment of brain tumors.

For more information on this topic, see the HealthLink article Healing with Light

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Light-Emitting Diode

The NASA Light-Emitting Diode Medical Program –
Progress in Space Flight and Terrestrial Applications
Abstract. This work is supported and managed through the NASA Marshall Space Flight Center – SBIR Program. Studies on cells exposed to microgravity and hypergravity indicate that human cells need gravity to stimulate cell growth. As the gravitational force increases or decreases, the cell function responds in a linear fashion. This poses significant health risks for astronauts in long term space flight. LED-technology developed for NASA plant grown experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. This LED-technology is also biologically optimal for photodynamic therapy of cancer.

LED-ENHANCEMENT OF CELL GROWTH
The application of light therapy with the use of NASA LED’s will significantly improve the medical care that is available to astronauts on long-term space missions. NASA LED’s stimulate the basic energy processes in the mitochondria (energy compartments) of each cell, particularly when near-infrared light is used to activate the color sensitive chemicals (chromophores, cytochrome systems) inside. Optimal LED wavelengths include 680, 730 and 880 nm. The depth of near-infrared light penetration into human tissue has been measured spectroscopically (Chance, et al 1988). Spectra taken from the wrist flexor muscles in the forearm and muscles in the calf of the leg demonstrate that most of the light photons at wavelengths between 630-800 nm travel 23 cm through the surface tissue and muscle between input and exit at the photon detector. Our laboratory has improved the healing of wounds in laboratory animals by using NASA LED light and hyperbaric oxygen. Furthermore, DNA synthesis in fibroblasts and muscle cells has been quintupled using NASA LED light alone, in a single application combining 680, 730, and 880 nm each at 4 Joules per centimeter squared.

Muscle and bone atrophy are well documented in astronauts, and various minor injuries occurring in space have been reported not to heal until landing on Earth. Long term space flight, with its many inherent risks, also raises the possibility of astronauts being injured performing their required tasks. The fact that the normal healing process is negatively affected by microgravity requires novel approaches to improve wound healing and tissue growth in space. NASA LED arrays have already flown on Space Shuttle missions for studies of plant growth. The U.S. Food and Drug Administration (FDA) has approved human trials. The use of light therapy with LED’s is an approach to help increase the rate of wound healing in the microgravity environment, reducing the risk of treatable injuries becoming mission catastrophes.

Wounds heal less effectively in space than here on Earth. Improved wound healing may have multiple applications which benefit civilian medical care, military situations and long-term space flight. Laser light and hyperbaric oxygen have been widely acclaimed to speed wound healing in ischemic, hypoxic wounds. An excellent review of recent human experience with near-infrared light therapy for wound healing was published by Conlan, et al in 1996. Lasers provide low energy stimulation of tissues which results in increased cellular activity during wound healing (Beauvoit, 1989, 1995; Eggert, 1993; Karu, 1989; Lubart, 1992, 1997; Salansky, 1998; Whelan, 1999; Yu, 1997). Some of these activities include increased fibroblast proliferation, growth factor syntheses, collagen production and angiogenesis.

Lasers, however, have some inherent characteristics, which make their use in a clinical setting problematic, including limitations in wavelengths and beam width. The combined wavelengths of light optimal for wound healing cannot be efficiently produced, and the size of wounds which may be treated by lasers is limited. Light-emitting diodes (LED’s) offer an effective alternative to lasers. These diodes can be made to produce multiple wavelengths, and can be arranged in large, flat arrays allowing treatment of large wounds. Our experiments suggest potential for using LED light therapy at 680, 730 and 880 nm simultaneously, alone and in combination with hyperbaric oxygen therapy, both alone and in combination, to accelerate the healing process in Space Station Missions, where prolonged exposure to microgravity may otherwise retard healing. NASA LED’s have proven to stimulate wound healing at near-infrared wavelengths of 680, 730 and 880 nm in laboratory animals, and have been approved by the U.S. Food and Drug Administration (FDA) for human trials. Furthermore, near-infrared LED light has quintupled the growth of fibroblasts and muscle cells in tissue culture. The NASA LED arrays are light enough and mobile enough to have already flown on the Space Shuttle numerous times. LED arrays may prove to be useful for improving wound healing and treating problem wounds, as well as speeding the return of deconditioned personnel to full duty performance. Potential benefits to NASA, military, and civilian populations include treatment of serious burns, crush injuries, non-healing fractures, muscle and bone atrophy, traumatic ischemic wounds, radiation tissue damage, compromised skin grafts, and tissue regeneration.

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